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KMID : 0355620080340030276
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Journal of Korean Association of Oral and Maxillofacial Surgeons
2008 Volume.34 No. 3 p.276 ~ p.284
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Effect of calcium and vitamin D supplementation on bone formation around titanium implant in osteoporosis-induced rats
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Lee Jae-Yeol
Jeong Seok-Young
Shin Sang-Hun
Kim Gyoo-Cheon
Kim Yong-Deok
Jung In-Kyo
Kim Uk-Kyu
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Abstract
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Purpose:The purpose of this study was to observe the effect of calcium and vitamin D to the titanium implant osseointegration in the osteoporosis-induced animal model.
Material and Methods :Thirty-two rats, 10 weeks of age, were divided into two groups: experimental group was ingested additional calcium and vitamin D , and a control group was not. Titanium screw implant(diameter, 2.0 mm; length, 3.5 mm; pitch-height 0.4 mm) were placed into tibia of 32 rats, 16 in the control group and 16 in the experimental group. The rats were sacrificed at 1, 2, 4 and 8 weeks after implantation for histopathologic examination, histomorphometric analysis and immunohistochemistry with fibronectin and collagen type I antibody.
Results:In histopathological findings, newly formed bone was seen at 2 weeks and became lamellar bone at 4 weeks, and mature trabecullar bone was seen at 8 weeks in experimental group. In control group, thickness of regenerated bone increased till 4 weeks gradually and trabecullar bone was seen at 8 weeks. In histomorphometric analysis, marrow bone density increased significantly in experimental group compared to control group. Fibronectin immunoreactivity was strong at 2 weeks in experimental group and reduced after 4 weeks gradually. But it was maintained continuously from 2 to 8 weeks in control group. Collagen type I immunoreactivity was very strong from 2 to 4 week in experimental group. And the amount of Collagen type I expression was more abundant in experimental group.
Conclusion: The results of this study suggest that calcium and vitamin D supplementation promote bone healing around titanium implants in osteoporosis induced animals.
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KEYWORD
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Osteoporosis, Implant, Calcium, Vitamin D
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